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Cell directional migration and oriented division on three-dimensional laser-induced periodic surface structures on polystyrene
2008 (English)In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 29, no 13, p. 2049-2059Article in journal (Refereed) Published
Abstract [en]

The extracellular matrix in animal tissues usually provides a three-dimensional structural support to cells in addition to performing various other important functions. In the present study, wavy submicrometer laser-irradiated periodic surface structures (LIPSS) were produced on a smooth polystyrene film by polarized laser irradiation with a wavelength of 266 nm. Rat C6 glioma cells exhibited directional migration and oriented division on laser-irradiated polystyrene, which was parallel to the direction of LIPSS. However, rat C6 glioma cells on smooth polystyrene moved in a three-step invasion cycle, with faster migation speed than that on laser-irradiated polystyrene. In addition, focal adhesions examined by immunostaining focal adhesion kinase in human epithelial carcinoma HeLa cells were punctuated on smooth polystyrene, whereas dash-like on laser-irradiated polystyrene. We hypothesized that LIPSS on laser-irradiated polystyrene acted as an anisotropic and persistent mechanical stimulus to guide cell anisotropic spreading, migration and division through focal adhesions.

Place, publisher, year, edition, pages
2008. Vol. 29, no 13, p. 2049-2059
Keywords [en]
laser irradiation, polystyrene, cell migration, cell division
National Category
Polymer Chemistry Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-129150DOI: 10.1016/j.biomaterials.2007.12.047ISI: 000256853100006PubMedID: 18272216OAI: oai:DiVA.org:umu-129150DiVA, id: diva2:1058417
Available from: 2016-12-21 Created: 2016-12-21 Last updated: 2018-06-09Bibliographically approved

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Ohlin, Christian A.

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