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Using phosphate supplementation to reverse hypophosphatemia and phosphate depletion in neurological disease and disturbance
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
2016 (English)In: Nutritional neuroscience, ISSN 1028-415X, E-ISSN 1476-8305, Vol. 19, no 5, 213-223 p.Article in journal (Refereed) Published
Abstract [en]

Hypophosphatemia (HP) with or without intracellular depletion of inorganic phosphate (Pi) and adenosine triphosphate has been associated with central and peripheral nervous system complications and can be observed in various diseases and conditions related to respiratory alkalosis, alcoholism (alcohol withdrawal), diabetic ketoacidosis, malnutrition, obesity, and parenteral and enteral nutrition. In addition, HP may explain serious muscular, neurological, and haematological disorders and may cause peripheral neuropathy with paresthesias and metabolic encephalopathy, resulting in confusion and seizures. The neuropathy may be improved quickly after proper phosphate replacement. Phosphate depletion has been corrected using potassium-phosphate infusion, a treatment that can restore consciousness. In severe ataxia and tetra paresis, complete recovery can occur after adequate replacement of phosphate. Patients with multiple risk factors, often with a chronic disease and severe HP that contribute to phosphate depletion, are at risk for neurologic alterations. To predict both risk and optimal phosphate replenishment requires assessing the nutritional status and risk for re-feeding hypophosphatemia. The strategy for correcting HP depends on the severity of the underlying disease and the goal for re-establishing a phosphate balance to limit the consequences of phosphate depletion.

Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 19, no 5, 213-223 p.
Keyword [en]
Hypophosphatemia, Malnutrition, Refeeding syndrome, Nervous system
National Category
Neurosciences Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-129175DOI: 10.1179/1476830515Y.0000000024ISI: 000378144900004PubMedID: 25909152OAI: oai:DiVA.org:umu-129175DiVA: diva2:1058475
Available from: 2016-12-21 Created: 2016-12-21 Last updated: 2017-05-12Bibliographically approved

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Håglin, Lena
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