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Covariation between plasma phosphate and daytime cortisol in early Parkinson's disease
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
2016 (English)In: Brain and Behavior, ISSN 2162-3279, E-ISSN 2162-3279, Vol. 6, no 12, e00556Article in journal (Refereed) Published
Abstract [en]

Background: Disturbed phosphate homeostasis in early Parkinson′s disease (PD) may originate from a stress-related condition and nutritional status among other risk factors, age, and gender.

Methods: Risk of malnutrition using Mini-nutritional assessment (MNA score) and plasma levels of protein markers and daytime cortisol at the time of diagnosis in PD (n = 75) were compared with a control group (n = 24). Cognition was assessed using the Mini-Mental State Examination (MMSE score) and motor function using Unified Parkinson′s Disease Rating Scale (UPDRS-part III scale).

Results: The patients with PD had significantly lower MNA score than controls which correlated with plasma phosphate levels. The logistic regression revealed that increasing MNA protected from low plasma phosphate, final score (OR = 0.399; 95% CI = 0.196–0.816; p = .012) and total score (OR = 0.656; 95% CI = 0.422–1.018; p = .060). Phosphate correlated with albumin (r = .315; p < .006), transferrin (r = .331; p < .004) and cortisol (r = −0.355; p < .002) confirmed by logistic regressions. Increasing albumin protects from low phosphate after adjusting in logistic regression (OR = 0.806; 95% CI = 0.682–0.952; p = .011) and after including variables from Table 1 in backwards elimination, final step (OR = 0.800; 95% CI = 0.660–0.969; p = .022). MNA total score and cortisol correlated inversely, confirmed in logistic regression for MNA total score (OR = 0.786; 95% CI = 0.627–0.985; p = .037) and for MNA initial score (OR = 0.650; 95% CI = 0.453–0.930; p = .020).

Conclusion: This study highlights the importance of phosphate for optimal nutritional status by association with MNA score and albumin in plasma. An inverse relationship between phosphate and cortisol indicate, in addition, that low phosphate levels may affect cognition and motor function in PD.

Place, publisher, year, edition, pages
2016. Vol. 6, no 12, e00556
Keyword [en]
albumin, cognition, cortisol, Mini-nutritional Assessment, Parkinson´s disease, phosphate, stress, transferrin
National Category
Neurosciences Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-129231DOI: 10.1002/brb3.556ISI: 000392712000003OAI: oai:DiVA.org:umu-129231DiVA: diva2:1058576
Available from: 2016-12-21 Created: 2016-12-21 Last updated: 2017-02-27Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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