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Effect of GT-Peptide 10 and Triethyl Citrate on P. acnes Biofilm Formation, Viability, and Dispersion
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
2016 (English)In: Journal of drugs in dermatology, ISSN 1545-9616, Vol. 15, no 6, 778-781 p.Article in journal (Refereed) Published
Abstract [en]

Background: P. acnes biofilms are emerging topics in acne vulgaris pathogenesis and may be responsible for antibiotic tolerance. Objective: To investigate the efficacy of GT peptide 10 either alone or in combination with triethyl citrate (TEC) in in vitro model of P acnes biofilm. Methods: Six-day-old P acnes biofilms were treated with various concentrations of these substances and biofilm dispersion and cell viability were monitored. Results: A 24-hour exposure of preformed biofilms to a combination of GT peptide 10/TEC led to killing of up to 92% of bacterial cells inside the biofilm. Neither the single substance nor the combination of both substances affected the biofilm integrity or resulted in biofilm dispersal. Conclusions: A combination of GT peptide 10/TEC shows antibacterial effects in in vitro model of P. acnes biofilm.

Place, publisher, year, edition, pages
2016. Vol. 15, no 6, 778-781 p.
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:umu:diva-129219ISI: 000387935700021PubMedID: 27272091OAI: oai:DiVA.org:umu-129219DiVA: diva2:1059565
Available from: 2016-12-22 Created: 2016-12-21 Last updated: 2016-12-22Bibliographically approved

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Eilers, HinnerkAlexeyev, Oleg A.
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