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Exposing the exposures responsible for type 2 diabetes and obesity
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
2016 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 354, no 6308, p. 69-73Article, review/survey (Refereed) Published
Abstract [en]

The rising prevalences of type 2 diabetes and obesity constitutemajor threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.

Place, publisher, year, edition, pages
2016. Vol. 354, no 6308, p. 69-73
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-129211DOI: 10.1126/science.aaf5094ISI: 000387777900030PubMedID: 27846494OAI: oai:DiVA.org:umu-129211DiVA, id: diva2:1059581
Note

Special Issue: SI

Available from: 2016-12-22 Created: 2016-12-21 Last updated: 2018-06-09Bibliographically approved

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Franks, Paul W.

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