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Decreased Symptoms without Augmented Skin Blood Flow in Subjects with RLS/WED after Vibration Treatment
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Section of Medicine.
2016 (English)In: Journal of Clinical Sleep Medicine (JCSM), ISSN 1550-9389, E-ISSN 1550-9397, Vol. 12, no 7, p. 947-952Article in journal (Refereed) Published
Abstract [en]

Study Objectives: Vascular disturbances leading to tissue hypoxia have been named as a possible cause for RLS/WED. Vibration to the whole body (WBV) in subjects with RLS/WED results in increased skin blood flow (SBF). The aims of this investigation were to (1) determine if a two-week treatment with WBV will decrease symptoms associated with RLS/WED and, (2) if so, determine if the mechanism for improvement in symptoms is related to an increase in SBF, as measured in flux. Methods: Eleven subjects with RLS/WED underwent 2 weeks of 14-minute intermittent WBV and a 2-week sham treatment in randomized order. Pre and post intervention RLS symptom severity were compared. Baseline SBF was compared between subjects with RLS/WED and an age-and sex-matched control group. A crossover design (aim 1) and a matched case-control design and repeated measures design (aim 2) were used. The data analyses consisted of 2-sample and paired t-tests; where applicable we used a standard crossover design adjustment. Results: WBV did significantly decrease symptoms associated with RLS/WED compared to baseline data and compared to sham treatment. The baseline flux was significantly lower in RLS/WED subjects than matched controls, but this deficit was negated with WBV. There was no increase in resting SBF over the 2 weeks of treatment. Conclusions: Subjects with RLS/WED have decreased SBF but are able to increase flux to the same level as normal subjects with WBV. A 2-week intervention with WBV decreases symptoms associated with RLS/WED, but this does not seem to be related to an increase in resting SBF.

Place, publisher, year, edition, pages
2016. Vol. 12, no 7, p. 947-952
Keywords [en]
restless legs syndrome, WBV, hypoxia
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-129780DOI: 10.5664/jcsm.5920ISI: 000389988200003PubMedID: 27070250OAI: oai:DiVA.org:umu-129780DiVA, id: diva2:1062830
Available from: 2017-01-09 Created: 2017-01-09 Last updated: 2019-05-22Bibliographically approved

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Ulfberg, Jan

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