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Tissue-specific uptake of the benzodiazepine oxazepam in adult Eurasian perch (Perca fluviatilis)
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences. Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
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2016 (English)In: Environmental Chemistry, ISSN 1448-2517, E-ISSN 1449-8979, Vol. 13, no 5, 849-853 p.Article in journal (Refereed) Published
Abstract [en]

Psychoactive substances are used worldwide and constitute one of the common groups of pharmaceutical contaminants in surface waters. Typically, in field surveys and laboratory studies, muscle or whole - body homogenates are used to quantify pharmaceutical concentrations in biota, although uptake of pharmaceuticals may be tissue - specific. Therefore, the aim of this study was to investigate the tissue - specific (muscle, liver, brain and blood plasma) uptake of the anxiolytic oxazepam in adult Eurasian perch (Perca fluviatilis). In laboratory experiments, perch were exposed to four different concentrations (2, 4, 12 and 20 mu g L-1) of oxazepam for 6 days, and muscle, liver, brain tissue and blood plasma were sampled to determine tissue - specific bioconcentration. We found that the tissue - specific bioconcentration was independent of oxazepam concentration. However, among tissue types, bioconcentration was significantly different, with the concentration in muscle, liver = brain, blood plasma. Hence, it is important to consider the type of tissue used to quantify pharmaceutical uptake in fish, for predictions of species - specific sensitivity and comparisons across studies. Furthermore, our results indicate a somewhat lower transportability (brain/plasma ratio 0.54) of oxazepam from blood to brain in fish compared with in mammals, which should be kept in mind when employing 'read - across' approaches.

Place, publisher, year, edition, pages
2016. Vol. 13, no 5, 849-853 p.
Keyword [en]
blood concentration, brain concentration, distribution coefficient, pharmaceutical pollution, tissue-specific bioconcentration
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:umu:diva-129936DOI: 10.1071/EN16027ISI: 000384432600008OAI: oai:DiVA.org:umu-129936DiVA: diva2:1064022
Available from: 2017-01-11 Created: 2017-01-10 Last updated: 2017-01-11Bibliographically approved

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Heynen, MartinaBrodin, TomasKlaminder, JonatanJonsson, MicaelFick, Jerker
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CiteExportLink to record
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Citation style
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