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Depression – en riskfaktor för demens?
Umeå University, Faculty of Social Sciences, Department of Psychology.
2016 (Swedish)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [sv]

Depression kan vara associerad med en ökad risk för demens. Dock är förståelsen för sambandet begränsat och rönen motsägelsefulla. Syftet med denna studie var att undersöka associationen mellan depression hos äldre och demens, såväl som att undersöka vilken inverkan kön och typ av demens har på associationen. Studiens sample bestod av 1832 individer utan demens, i åldern 60 år och över. Vid uppföljningen diagnostiserades 262 deltagare med demens. Cox regressionsanalys användes för att undersöka sambandet mellan depression och demens, inkluderat kön och typ av demens. Resultaten visade en signifikant association mellan depression och demens (riskförhållande (HR) 1,67, 95 % konfidensintervall (CI) = 1,22–2,29). Dessutom var depression förknippad med signifikant ökad risk för demens hos män (riskförhållande (HR) 1,76, 95 % konfidensintervall (CI) = 1,01–3,07) och kvinnor (riskförhållanden (HR) 1,66, 95 % konfidensintervall (CI) = 1,14–2,24). Analysen visade en signifikant association mellan depression och Alzheimers sjukdom (riskförhållande (HR) 1,89, 95 % konfidensintervall (CI) = 1,27–2,81), medan det inte fanns någon signifikant association med vaskulär demens (p = ,133).  Depression är signifikant associerad med demens och Alzheimers sjukdom, oavsett kön.  Dessa resultat tyder på att ytterligare forskning bör fokusera på sambandet mellan specifika typer av depression och demens.

Abstract [en]

Depression may be associated with increased risk of developing dementia. However, the association is still poorly understood and the findings are contradictory. The aim of this study was to investigate the association between depression and dementia in an elderly population, as well as to examine how sex and how the type of dementia influence the association. The study sample comprised 1832 individuals without dementia, aged 60 years and over. During follow-up, 262 participants were diagnosed with dementia. Cox regression analysis was used to examine the association between depression and dementia, accounted for gender and the type of dementia. The results showed a significant association of depression and dementia (hazard ratio (HR) 1.67, 95% confidence interval (CI) = 1.22–2.29).  Furthermore, depression significantly increased the risk for dementia in men (hazard ratio (HR) 1.76, 95% confidence interval (CI) = 1.01–3.07) and women (hazard ratio (HR) 1.66, 95% confidence interval (CI) = 1.14–2.24). The analysis showed a significant association between depression and Alzheimer’s disease (hazard ratio (HR) 1.89, 95% confidence interval (CI) = 1.27–2.81), whereas there were no significant association with vascular dementia (p = .133). Depression is significantly associated with dementia and Alzheimer’s disease, regardless of gender. These findings suggest that further research should address the association between specific subtypes of depression and dementia.

Place, publisher, year, edition, pages
2016. , 18 p.
Keyword [en]
dementia, Alzheimer's disease, vascular dementia, depression, risk factors, longitudinal
Keyword [sv]
demens, Alzheimers sjukdom, vaskulär demens, depression, riskfaktorer, longitudinell
National Category
Psychology
Identifiers
URN: urn:nbn:se:umu:diva-130047OAI: oai:DiVA.org:umu-130047DiVA: diva2:1064068
Subject / course
Examensarbete i psykologi
Educational program
Study Programme for University Diploma in Psychology
Supervisors
Examiners
Available from: 2017-01-12 Created: 2017-01-11 Last updated: 2017-01-12Bibliographically approved

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