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Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. International inflammation (in-FLAME) network of the World Universities Network.
2016 (English)In: Expert Review Of Clinical Immunology, ISSN 1744-666X, Vol. 12, no 6, 625-639 p.Article, review/survey (Refereed) Published
Abstract [en]

Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic manifestations. Because of very low quality evidence and heterogeneity between studies, specific advice on the most effective regimens cannot yet be given -not even for eczema prevention. To be able to adopt results into specific recommendations, international expert organizations stress the need for well-designed studies.

Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 12, no 6, 625-639 p.
Keyword [en]
Diversity, dysbiosis, eczema, gut microbiome, hygiene hypothesis, primary prevention, probiotic
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-130125DOI: 10.1586/1744666X.2016.1147955ISI: 000388687300005PubMedID: 26821735OAI: oai:DiVA.org:umu-130125DiVA: diva2:1064117
Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-01-11Bibliographically approved

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CiteExportLink to record
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Citation style
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