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Optimisation of one-step desolvation and scale-up of gelatine nanoparticle production
Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians Universität München, Munich, Germany.
2016 (English)In: Journal of Microencapsulation, ISSN 0265-2048, E-ISSN 1464-5246, Vol. 33, no 7, 595-604 p.Article in journal (Refereed) Published
Abstract [en]

Gelatine nanoparticles (GNPs) are biodegradable and biocompatible drug delivery systems with excellent clinical performances. A two-step desolvation is commonly used for their preparation, although this methodology has several shortcomings: lack of reproducibility, small scales and low yields. A straightforward and more consistent GNP preparation approach is presented here focusing on the development of a one-step desolvation with the use of a commercially available gelatine type. Controlled stirring conditions and ultrafiltration are used to achieve large-scale production of nanoparticles of up to 2.6g per batch. Particle size distributions are conserved and comparable to those determined for two-step desolvation on small scale. Additionally, a range of cross-linking agents is examined for their effectiveness in stabilising GNPs as an alternative to glutaraldehyde. Glyceraldehyde demonstrated outstanding properties, which led to high colloidal stability. This approach optimises the manufacturing process and the scale-up of the production capacity, providing a clear potential for future applications.

Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 33, no 7, 595-604 p.
Keyword [en]
Gelatine nanoparticles, one-step desolvation, scale-up, cross-linking, AF4
National Category
Pharmaceutical Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-130105DOI: 10.1080/02652048.2016.1228706ISI: 000389219700001OAI: oai:DiVA.org:umu-130105DiVA: diva2:1064836
Available from: 2017-01-13 Created: 2017-01-11 Last updated: 2017-01-13Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • de-DE
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  • nn-NB
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  • Other locale
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