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HSV presence in brains of individuals without dementia: the TASTY brain series
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
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2016 (English)In: Disease Models and Mechanisms, ISSN 1754-8403, E-ISSN 1754-8411, Vol. 9, no 11, 1349-1355 p.Article in journal (Refereed) Published
Abstract [en]

Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology. We investigated the prevalence of HSV type 1 and 2 in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology. HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, of which six had Alzheimer's disease neuropathological amyloid beta (A beta) aggregations. Additionally, serological data revealed 86% of serum samples tested were IgG-positive for HSV. In conclusion, we report epidemiological evidence of the presence of HSV in brain tissue free from encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence of 1.9%). Whereas 6/11 samples with HSV DNA in the brain tissue had A beta aggregations, most of those with A beta aggregations did not have HSV present in the brain tissue.

Place, publisher, year, edition, pages
2016. Vol. 9, no 11, 1349-1355 p.
Keyword [en]
Herpes simplex virus, Amyloid beta aggregations, Alzheimer's disease, PCR detection, Human brain tissue, Paraffin-embedded samples
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:umu:diva-129884DOI: 10.1242/dmm.026674ISI: 000387581000011PubMedID: 27664135OAI: oai:DiVA.org:umu-129884DiVA: diva2:1065531
Available from: 2017-01-16 Created: 2017-01-10 Last updated: 2017-01-16Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
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  • en-US
  • fi-FI
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  • nn-NB
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  • Other locale
More languages
Output format
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