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Plasma Levels of Fatty Acid-Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes A 22-Year Prospective Study
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2016 (English)In: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 36, no 11, 2259-2267 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To examine select adipokines, including fatty acid–binding protein 4, retinol-binding protein 4, and high-molecular-weight (HMW) adiponectin in relation to cardiovascular disease (CVD) mortality among patients with type 2 diabetes mellitus.

Approach and Results: Plasma levels of fatty acid–binding protein 4, retinol-binding protein 4, and HMW adiponectin were measured in 950 men with type 2 diabetes mellitus in the Health Professionals Follow-up Study. After an average of 22 years of follow-up (1993–2015), 580 deaths occurred, of whom 220 died of CVD. After multivariate adjustment for covariates, higher levels of fatty acid–binding protein 4 were significantly associated with a higher CVD mortality: comparing extreme tertiles, the hazard ratio and 95% confidence interval of CVD mortality was 1.78 (1.22–2.59; P trend=0.001). A positive association was also observed for HMW adiponectin: the hazard ratio (95% confidence interval) was 2.07 (1.42–3.06; P trend=0.0002), comparing extreme tertiles, whereas higher retinol-binding protein 4 levels were nonsignificantly associated with a decreased CVD mortality with an hazard ratio (95% confidence interval) of 0.73 (0.50–1.07; P trend=0.09). A Mendelian randomization analysis suggested that the causal relationships of HMW adiponectin and retinol-binding protein 4 would be directionally opposite to those observed based on the biomarkers, although none of the Mendelian randomization associations achieved statistical significance.

Conclusions: These data suggest that higher levels of fatty acid–binding protein 4 and HMW adiponectin are associated with elevated CVD mortality among men with type 2 diabetes mellitus. Biological mechanisms underlying these observations deserve elucidation, but the associations of HMW adiponectin may partially reflect altered adipose tissue functionality among patients with type 2 diabetes mellitus.

Place, publisher, year, edition, pages
2016. Vol. 36, no 11, 2259-2267 p.
Keyword [en]
adipokines, adiponectin, cardiovascular disease, fatty acid-binding proteins, heart failure
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-129882DOI: 10.1161/ATVBAHA.116.308320ISI: 000387051500022PubMedID: 27609367OAI: oai:DiVA.org:umu-129882DiVA: diva2:1065907
Available from: 2017-01-17 Created: 2017-01-10 Last updated: 2017-01-17Bibliographically approved

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CiteExportLink to record
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Citation style
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