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Sickness behaviors (reduced social interaction and pain behaviors) are linked to inflammatory mechanisms in a rat model of work-related musculoskeletal disorders
Department of Anatomy and Cell biology, Temple University, Philadelphia, USA.
Department of Surgery, University of Pennsylvania, USA.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Department of Neurosurgery, Thomas Jefferson University, USA.
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2016 (English)In: Proceedings of the Human Factors and Ergonomics Society Annual Meeting, ISSN 1541-9312, Vol. 60, no 1, 975-979 p.Article in journal (Refereed) Published
Abstract [en]

We sought to determine if sickness behaviors (decreased social interaction and pain) are induced in a rat model of work-related overuse and effectiveness of anti-inflammatory treatments. Rats first trained to learn a high force reaching task (15 min/week day for 6 wks), with subsets treated prophylactically with ibuprofen or anti-TNFalpha. Others performed a high repetition high force (HRHF) task for 6 or 12 weeks (2 hrs/day, 3 days/wk) untreated, or with ibuprofen, anti-TNFalpha or rest treatments beginning task week 5. Untreated HRHF rats had increased IL-1beta, IL-6 and TNFalpha in serum and brain, increased Substance P in spinal cord, decreased social interaction and increased forepaw allodynia. Secondary antiinflammatory treatments attenuated social interaction and brain changes, but not allodynia or spinal cord changes; rest provided partial attenuation. Prophylactic treatments prevented all changes. Thus, inflammatory mechanisms mediate the development of sickness behaviors induced by work-related overuse, but not maintenance of allodynia.

Place, publisher, year, edition, pages
Sage Publications, 2016. Vol. 60, no 1, 975-979 p.
Keyword [en]
behaviour, inflammation
National Category
Rheumatology and Autoimmunity
Research subject
didactics of educational measurement; Biochemistry; Biopharmaceutics
Identifiers
URN: urn:nbn:se:umu:diva-130360DOI: 10.1177/1541931213601225OAI: oai:DiVA.org:umu-130360DiVA: diva2:1066469
Available from: 2017-01-18 Created: 2017-01-18 Last updated: 2017-03-19Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf