umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Associations between genome-wide gene expression and ambient nitrogen oxides (NOx)
Show others and affiliations
2017 (English)In: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 28, no 3, 320-328 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: We hypothesize that biological perturbations due to exposure to ambient air pollution are reflected in gene-expression levels in peripheral blood mononuclear cells.

METHODS: We assessed the association between exposure to ambient air pollution and genome-wide gene-expression levels in peripheral blood mononuclear cells collected from 550 healthy subjects participating in cohorts from Italy and Sweden. Annual air pollution estimates of nitrogen oxides (NOx) at time of blood collection (1990 to 2006) were available from the ESCAPE study. In addition to univariate analysis and two variable selection methods to investigate the association between expression and exposure to NOx, we applied gene set enrichment analysis to assess overlap between our most perturbed genes and gene sets hypothesized to be related to air pollution and cigarette smoking. Finally, we assessed associations between NOx and CpG island methylation at the identified genes.

RESULTS: Annual average NOx exposure in the Italian and Swedish cohorts was 94.2 µg/m3, and 6.7 µg/m3, respectively. Long-term exposure to NOx was associated with seven probes in the Italian cohort and one probe in the Swedish (and combined) cohorts. For genes AHCYL2 and MTMR2 changes were also seen in the methylome. Genes hypothesized to be downregulated due to cigarette smoking were enriched among the most strongly downregulated genes from our study.

CONCLUSION: This study provides evidence of subtle changes in gene expression related to exposure to long-term NOx. On a global level the observed changes in the transcriptome may indicate similarities between air pollution and tobacco induced changes in the transcriptome.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017. Vol. 28, no 3, 320-328 p.
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-131135DOI: 10.1097/EDE.0000000000000628ISI: 000398158000014PubMedID: 28151741OAI: oai:DiVA.org:umu-131135DiVA: diva2:1071812
Available from: 2017-02-06 Created: 2017-02-06 Last updated: 2017-05-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Modig, LarsBergdahl, Ingvar A
By organisation
Occupational and Environmental MedicineDepartment of Biobank Research
In the same journal
Epidemiology
Environmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 20 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf