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Correlation between Salivary LL-37, Caries associated Bacteria and Dental Caries in Children with various Vitamin D levels
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
2016 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Scientific observations suggest that antibacterial peptides and its association with caries and vitamin D levels could possibly be used as a prognostic tool and even as a treatment in the future. It is an area in need of further research to firmly establish significant value to science.

 

47 children were studied, all participating in a follow-up study (DviTand) from the original project Divisum where levels of 1,25D3 (vitamin D) were measured. The correlation between levels of vitamin D in blood and presence of the antibacterial peptide LL-37 in saliva was evaluated. Regular dental check-up was performed and sampling of dental plaque and stimulated saliva was gathered on all children. Tooth biofilm and presence of caries associated bacteria in relation to diet were analyzed.

 

54.3 % of the children had clinically observed dental caries. Children with caries tend to have more S.mutans, higher daily milk intake, higher levels of LL-37 and lower levels of vitamin D than children with no caries, though without significant differences. Children with low vitamin D levels tend to have higher levels of LL-37, without significant differences. Supplementation with vitamin D correlated with presence of caries in a significantly lesser extent than those not taking supplement. Children with dark skin, according to Fitzpatrick scale, were more likely to use supplements.

 

The clinical trials indicate that more significant results might be achieved with higher number of participants enrolled and right criteria included. Supplements might compensate for lack of sunlight exposure or biological disadvantages to generate important metabolites from vitamin D.

Place, publisher, year, edition, pages
2016.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-131239OAI: oai:DiVA.org:umu-131239DiVA: diva2:1073057
External cooperation
VLL
Educational program
Dentistry Programme
Supervisors
Examiners
Available from: 2017-02-09 Created: 2017-02-09 Last updated: 2017-02-09Bibliographically approved

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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf