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The impact of socio-economic factors on treatment choice and mortality in chronic myeloid leukaemia
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. (Sundsvall Research Unit, Umeå University)
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2017 (Engelska)Ingår i: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 98, nr 4, s. 398-406Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

PURPOSE: To evaluate the influence of socio-economic variables on treatment selection and survival of patients with chronic myeloid leukaemia (CML).

METHODS: Using information available in population-based Swedish registries, we evaluated indices of health, education and economy from the 980 patients in the Swedish CML register diagnosed between 2002 and 2012. Apart from internal comparisons, five age-, gender- and region-matched control subjects per patient served as control cohort. Median follow-up time from CML diagnosis was 4.8 years.

RESULTS: Among patients with CML, low personal or household income, short education, living alone, poor performance status and high age (>60 years) were significantly associated with an inferior survival (in univariate analyses). However, similar findings were noted also in the matched control group, and in comparisons adjusted for calendar year, age and performance status, socio-economic variables were not significantly associated with CML survival. Meanwhile, both education and income were independently linked to TKI treatment overall and to upfront treatment with second-generation TKIs.

CONCLUSIONS: In conclusion, socio-economic conditions were associated with survival in the studied CML cohort but these associations could be explained by differences at baseline. Meanwhile, socio-economic conditions appeared to influence treatment choice.

Ort, förlag, år, upplaga, sidor
2017. Vol. 98, nr 4, s. 398-406
Nyckelord [en]
chronic myelogenous leukaemia, cohort studies, epidemiology, mortality, socioeconomic factors
Nationell ämneskategori
Hematologi
Identifikatorer
URN: urn:nbn:se:umu:diva-131365DOI: 10.1111/ejh.12845ISI: 000397536300014PubMedID: 28009456OAI: oai:DiVA.org:umu-131365DiVA, id: diva2:1073787
Tillgänglig från: 2017-02-13 Skapad: 2017-02-13 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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