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C-11-Acetate-PET/CT Compared to Tc-99m-HDP Bone Scintigraphy in Primary Staging of High-risk Prostate Cancer
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
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2016 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 36, no 12, 6475-6479 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of this study was to evaluate the detection rate of bone metastases and the added value of C-11-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). Materials and Methods: A total of 66 untreated patients with high-risk PC with ACE-PET/CT and planar BS findings within 3 months of each other were retrospectively enrolled. Findings were compared and verified with follow-up data after an average of 26 months. Results: The rate of detection of bone metastases was superior with ACE-PET/CT compared to BS (p<0.01). Agreement between the methods and between BS and follow-up was moderate (Cohen's kappa coefficient of 0.64 and 0.66, respectively). Agreement between ACE-PET/CT and follow-up was excellent (kappa coefficient of 0.95). Therapy was changed in 11% of patients due to ACE-PET/CT results. Conclusion: ACE-PET/CT performed better than planar BS in detection of bone metastases in high-risk PC. ACE-PET/CT findings influenced clinical management.

Place, publisher, year, edition, pages
2016. Vol. 36, no 12, 6475-6479 p.
Keyword [en]
Prostate cancer, PET/CT, [C-11]-acetate, bone scintigraphy, bone metastasis
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-130998DOI: 10.21873/anticanres.11246ISI: 000390946700032PubMedID: 27919970OAI: oai:DiVA.org:umu-130998DiVA: diva2:1074880
Available from: 2017-02-16 Created: 2017-02-16 Last updated: 2017-02-16Bibliographically approved

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Strandberg, SaraKarlsson, Camilla ThellenbergÖgren, MattiasAxelsson, JanRiklund, Katrine
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