Patch testing with hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) - a multicentre study of the Swedish Contact Dermatitis Research Group
2017 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 76, no 1, 34-39 p.Article in journal (Refereed) Published
Background. In 2014, the fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series. Objectives. To study (i) whether fragrance mix (FM) II with 5% HICC detects more positive reactions than usual FM II with 2.5% HICC, and (ii) the reproducibility of patch testing with HICC. Methods. Two thousand one hundred and eighteen dermatitis patients at five Swedish dermatology departments were consecutively tested with FM II 14% pet., FM II 16.5% pet., and duplicate preparations of HICC 5% pet. Results. Of the patients, 3.2% reacted to FMII 14%, and 1.5% reacted to HICC. Separate testing with HICC detected 0.3% reactions without concomitant reactivity to FM II. FM II with 5% HICC did not give rise to more irritant reactions or signs of active sensitization than FM II with 2.5% HICC. Patch testing with duplicate applications of HICC increased the overall prevalence of HICC contact allergy to 1.9%. Conclusion. FMII with5% HICC does not detect more positive reactions than FMII with 2.5% HICC. Separate testing with HICC does not detect a sufficient proportion of patients who react only to HICC, without concomitant reactions to FMII, to warrant its inclusion in a baseline series.
Place, publisher, year, edition, pages
2017. Vol. 76, no 1, 34-39 p.
allergic contact dermatitis, contact allergy, delayed hypersensitivity, dose/area, fragrance, fragrance x II, high-performance liquid chromatography, hydroxyisohexyl 3-cyclohexene carboxaldehyde, CAS . 31906-04-4/51414-25-6
Dermatology and Venereal Diseases
IdentifiersURN: urn:nbn:se:umu:diva-130994DOI: 10.1111/cod.12699ISI: 000390785500005OAI: oai:DiVA.org:umu-130994DiVA: diva2:1074927