umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Diabetic retinopathy as a cause of visual impairment and blindness and the possibilities of prevention by using anti vascular endothelial growth factors.: A literature review
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Purpose of literature review

 Diabetic retinopathy is a very important public health problem and an important cause of visual impairment and blindness worldwide. In addition, visual impairment and blindness are very important public health problems. The number of diabetic retinopathy patients is expected to increase all over the world in the next few decades. In addition, diabetic retinopathy and its complications are still the leading causes of preventable blindness in working-age men and women. Anti-VEGFs have made a revolution in the prevention of visual impairment and blindness caused by diabetic retinopathy and its complications over the last ten years.

The aim of this literature review is to provide an overview of studies and articles which examined the role of Anti-VEGFs (Avastin and Lucentis)  in the prevention of visual impairment and blindness caused by diabetic retinopathy. 

Methodology

Pubmed database was searched for relevant articles, studies and clinical trials in humans about the role of anti vascular endothelial growth factors in the prevention of visual impairment and blindness caused by diabetic retinopathy. 

Results and discussion

In this review, sixteen studies and articles about the role of Anti-VEGFs in the prevention of visual impairment and blindness caused by diabetic retinopathy were found. These studies and articles emphasized on the role of intravitreal Anti-VEGFs in the treatment of diabetic retinopathy and diabetic macular edema and in the prevention of visual impairment and blindness in proliferative diabetic retinopathy and diabetic macular edema. Intravitreal Anti-VEGFs have shown good effects and promising results in their ability to make retinal neovascularization regress. But these Anti-VEGFs have an important limitation which is their short duration. In addition, these Anti-VEGFs cannot substitute the laser treatment which is the treatment of choice for proliferative diabetic retinopathy. 

Conclusion

The introduction of Anti-VEGFs into practice gave hope to many diabetic retinopathy patients facing the threat of visual impairment and blindness. However, using intravitreal Anti-VEGFs is a valuable additional treatment in proliferative diabetic retinopathy and diabetic macular edema to prevent visual impairment and reduce the chances of blindness.

Place, publisher, year, edition, pages
2016. , 39 p.
Series
Centre for Public Health Report Series, ISSN 1651-341x ; 2016:30
Keyword [en]
Diabetic retinopathy, proliferative diabetic retinopathy, Anti-VEGF, anti vascular endothelial growth factor, Avastin, Lucentis, blindness, prevention of blindness.
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-131626OAI: oai:DiVA.org:umu-131626DiVA: diva2:1075225
Educational program
Master's Programme in Public Health
Presentation
2016-05-23, Umeå Universitet, Umeå, 14:34 (English)
Supervisors
Examiners
Available from: 2017-02-17 Created: 2017-02-17 Last updated: 2017-02-17Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Bakouni, Ghalib Mohammed
By organisation
Epidemiology and Global Health
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 171 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf