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Pathogen-mediated manipulation of arthropod microbiota to promote infection
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
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2017 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 114, no 5, E781-E790 p.Article in journal (Refereed) Published
Abstract [en]

Arthropods transmit diverse infectious agents; however, the ways microbes influence their vector to enhance colonization are poorly understood. Ixodes scapularis ticks harbor numerous human pathogens, including Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis. We now demonstrate that A. phagocytophilum modifies the I. scapularis microbiota to more efficiently infect the tick. A. phagocytophilum induces ticks to express Ixodes scapularis antifreeze glycoprotein (iafgp), which encodes a protein with several properties, including the ability to alter bacterial biofilm formation. IAFGP thereby perturbs the tick gut microbiota, which influences the integrity of the peritrophic matrix and gut barrier-critical obstacles for Anaplasma colonization. Mechanistically, IAFGP binds the terminal D-alanine residue of the pentapeptide chain of bacterial peptidoglycan, resulting in altered permeability and the capacity of bacteria to form biofilms. These data elucidate the molecular mechanisms by which a human pathogen appropriates an arthropod antibacterial protein to alter the gut microbiota and more effectively colonize the vector.

Place, publisher, year, edition, pages
National Academy of Sciences , 2017. Vol. 114, no 5, E781-E790 p.
Keyword [en]
Anaplasma, Ixodes scapularis, antifreeze protein, biofilm, microbiome
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-132137DOI: 10.1073/pnas.1613422114ISI: 000393196300016PubMedID: 28096373OAI: oai:DiVA.org:umu-132137DiVA: diva2:1079648
Available from: 2017-03-09 Created: 2017-03-09 Last updated: 2017-11-29Bibliographically approved

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Yadav, Akhilesh K.Cava, Felipe
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Department of Molecular Biology (Faculty of Medicine)Molecular Infection Medicine Sweden (MIMS)
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Proceedings of the National Academy of Sciences of the United States of America
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CiteExportLink to record
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