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Screening of biocides, metals and antibiotics in Swedish sewage sludge and wastewater
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
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2017 (Engelska)Ingår i: Water Research, ISSN 0043-1354, E-ISSN 1879-2448, Vol. 115, s. 318-328Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Incoming sewage water, treated effluent and digested sludge were collected from 11 Swedish sewage treatment plants (STPs) on 3 different days. Analytical protocols were established for a large number of compounds (47) with antimicrobial properties and the collected samples were then screened for the presence of these selected substances. Liquid chromatography tandem mass spectrometry (LC-MS/MS) and inductively coupled plasma mass spectrometry (ICP-MS) were used to analyse the samples. Thirty organic compounds and 10 metals were detected above their respective detection limit. Quaternary ammonium compounds were the most abundant substances in the particulate phases with levels up to 370 μg/g and benzotriazoles were the most common in the aqueous phases with levels up to 24 μg/L. Several compounds with no, or very limited, previously reported data were detected in this study, including chlorhexidine, hexadecylpyridinium chloride and 10-benzalkonium chloride. Some of these were both frequently detected (>60% detection frequency) and found in high levels (up to 19 μg/g d.w. sludge). This study gives a comprehensive overview of the presence in Swedish STPs of a number of antimicrobial substances, providing crucial information in designing relevant studies on potential microbial co- and cross resistance development between antibiotics, biocides, and metals in the sewage system.

Ort, förlag, år, upplaga, sidor
Elsevier, 2017. Vol. 115, s. 318-328
Nyckelord [en]
Biocides, Antimicrobial, Antibiotics, Sewage water, Sludge, Wastewater
Nationell ämneskategori
Analytisk kemi
Identifikatorer
URN: urn:nbn:se:umu:diva-132432DOI: 10.1016/j.watres.2017.03.011ISI: 000399848200031OAI: oai:DiVA.org:umu-132432DiVA, id: diva2:1081358
Tillgänglig från: 2017-03-14 Skapad: 2017-03-14 Senast uppdaterad: 2018-10-11Bibliografiskt granskad
Ingår i avhandling
1. Antimicrobials in sewage treatment plants: occurrence, fate and resistance
Öppna denna publikation i ny flik eller fönster >>Antimicrobials in sewage treatment plants: occurrence, fate and resistance
2018 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Antimikrobiella ämnen i avloppsreningsverk : förekomst, avskiljning och resistens
Abstract [en]

The World Health Organization (WHO) has identified antibiotic resistance as a major threat to human health. The environment has been suggested to play an important role in the emergence of antibiotic resistant bacteria. The external environment can act as a source of resistance genes that could potentially be transferred into human pathogens. It is also an important route for the dissemination of antibiotic resistance genes and bacteria. Sewage treatment plants (STPs) are among the most important routes by which antibiotics and antibiotic resistance genes enter the environment. It has been suggested that STPs are hotspots for the development of antibiotic resistance because they contain relatively high concentrations of antibiotics as well as both human and environmental bacteria. Further complicating matters, there is evidence that other substances with antimicrobial properties, such as biocides and metals, can cause antibiotic resistance due to co- and cross-resistance.

This thesis contributes new knowledge on the concentrations, mass flows, and removal efficiencies of antimicrobials in STPs and their connections to the emergence of antibiotic resistance. Paper I presents data on the levels of 40 different antimicrobials in the incoming wastewater, treated effluent, and digested sludge of eleven different STPs. Although not previously detected in STPs, chlorhexidine is shown to be ubiquitous in such plants. In Paper II, mass flows and removal efficiencies are calculated for eleven antimicrobials over various treatment steps in three STPs, showing that polar antimicrobials were inefficiently removed from the wastewater. In Paper III, the minimum selective concentration (MSC) for the antibiotic tetracycline was determined in a complex bacterial aquatic biofilm using both phenotypic and genotypic endpoints. It was found that 10 µg/L selected for phenotypic resistance, and 1 µg/L selected for certain resistance genes. Paper VI used metagenomics to determine whether there is selection for antibiotic-resistant bacteria in STPs and whether the extent of this selection can be correlated to the concentrations of antimicrobial compounds. No clear evidence for selection was identified. Paper V evaluates advanced wastewater treatment techniques for removing antimicrobial compounds using ozonation and granular activated carbon (GAC). The identity of the GAC material was found to strongly affect removal efficiency, and GAC was more efficient than ozonation for most compounds at the tested concentrations.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå universitet, 2018. s. 77
Nyckelord
biocides, antibiotics, sewage treatment plants, wastewater, sludge, ozonation, activated carbon, antibiotic resistance, antimicrobials, mass flows, LC-MS/MS, environment, advanced water treatment
Nationell ämneskategori
Analytisk kemi
Identifikatorer
urn:nbn:se:umu:diva-152554 (URN)978-91-7601-938-2 (ISBN)
Disputation
2018-11-07, Aula Anatomica (Bio.A.206), Biologihuset, Umeå, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2018-10-17 Skapad: 2018-10-11 Senast uppdaterad: 2018-10-15Bibliografiskt granskad

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Östman, MarcusLindberg, Richard H.Fick, JerkerBjörn, ErikTysklind, Mats

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Water Research
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