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Epigenetic changes as prognostic predictors in endometrial carcinomas
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.ORCID iD: 0000-0001-9673-9982
2017 (English)In: Epigenetics, ISSN 1559-2294, E-ISSN 1559-2308, Vol. 12, no 1, 19-26 p.Article in journal (Refereed) Published
Abstract [en]

Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.

Place, publisher, year, edition, pages
2017. Vol. 12, no 1, 19-26 p.
Keyword [en]
DNA methylation, endometrial cancer, FIGO grade, prognosis
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-133259DOI: 10.1080/15592294.2016.1252891ISI: 000394449200003PubMedID: 27874289OAI: oai:DiVA.org:umu-133259DiVA: diva2:1088361
Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2017-04-12Bibliographically approved

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CiteExportLink to record
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  • apa
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