umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
A genetic association study of CSMD1 and CSMD2 with cognitive function
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 61, s. 209-216Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The complement cascade plays a role in synaptic pruning and synaptic plasticity, which seem to be involved in cognitive functions and psychiatric disorders. Genetic variants in the closely related CSMD1 and CSMD2 genes, which are implicated in complement regulation, are associated with schizophrenia. Since patients with schizophrenia often show cognitive impairments, we tested whether variants in CSMD1 and CSMD2 are also associated with cognitive functions per se. We took a discovery-replication approach, using well-characterized Scandinavian cohorts. A total of 1637 SNPs in CSMD1 and 206 SNPs in CSMD2 were tested for association with cognitive functions in the NCNG sample (Norwegian Cognitive NeuroGenetics; n = 670). Replication testing of SNPs with p-value < 0.001 (7 in CSMD1 and 3 in CSMD2) was carried out in the TOP sample (Thematically Organized Psychosis; n =1025) and the BETULA sample (Betula Longitudinal Study on aging, memory and dementia; n = 1742). Finally, we conducted a meta-analysis of these SNPs using all three samples. The previously identified schizophrenia marker in CSMD1 (SNP rs10503253) was also included. The strongest association was observed between the CSMDI SNP rs2740931 and performance in immediate episodic memory (p-value = 5 Chi 10(-6), minor allele A, MAF 0.48-0.49, negative direction of effect). This association reached the study-wide significance level (p <= 1.2 Chi 10(-5)). SNP rs10503253 was not significantly associated with cognitive functions in our samples. In conclusion, we studied n = 3437 individuals and found evidence that a variant in CSMD1 is associated with cognitive function. Additional studies of larger samples with cognitive phenotypes will be needed to further clarify the role of CSMD1 in cognitive phenotypes in health and disease.

Ort, förlag, år, upplaga, sidor
2017. Vol. 61, s. 209-216
Nyckelord [en]
Complement, Immunity, CSMD1, CSMD2, Schizophrenia, Cognition, Psychiatry, Memory, GWAS
Nationell ämneskategori
Psykiatri Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-133700DOI: 10.1016/j.bbi.2016.11.026ISI: 000395365900023PubMedID: 27890662OAI: oai:DiVA.org:umu-133700DiVA, id: diva2:1088993
Tillgänglig från: 2017-04-18 Skapad: 2017-04-18 Senast uppdaterad: 2018-11-12Bibliografiskt granskad

Open Access i DiVA

fulltext(851 kB)81 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 851 kBChecksumma SHA-512
a118ad46df9a3ae765d3b1c3845b7e659468f424e6af8d51eb274e476951508fd1e974539d9190af2a062df7d1be45557d64fb5bedfd7b6e1607390416ec41ad
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Nilsson, Lars-GöranKauppi, KarolinaAdolfsson, RolfNyberg, Lars

Sök vidare i DiVA

Av författaren/redaktören
Nilsson, Lars-GöranKauppi, KarolinaAdolfsson, RolfNyberg, Lars
Av organisationen
Umeå centrum för funktionell hjärnavbildning (UFBI)Institutionen för integrativ medicinsk biologi (IMB)PsykiatriInstitutionen för strålningsvetenskaper
I samma tidskrift
Brain, behavior, and immunity
PsykiatriNeurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 81 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 437 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf