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An updated evolutionary classification of CRISPR-Cas systems.
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2015 (English)In: Nature Reviews Microbiology, ISSN 1740-1526, E-ISSN 1740-1534, Vol. 13, no 11, 722-736 p.Article in journal (Refereed) Published
Abstract [en]

The evolution of CRISPR-cas loci, which encode adaptive immune systems in archaea and bacteria, involves rapid changes, in particular numerous rearrangements of the locus architecture and horizontal transfer of complete loci or individual modules. These dynamics complicate straightforward phylogenetic classification, but here we present an approach combining the analysis of signature protein families and features of the architecture of cas loci that unambiguously partitions most CRISPR-cas loci into distinct classes, types and subtypes. The new classification retains the overall structure of the previous version but is expanded to now encompass two classes, five types and 16 subtypes. The relative stability of the classification suggests that the most prevalent variants of CRISPR-Cas systems are already known. However, the existence of rare, currently unclassifiable variants implies that additional types and subtypes remain to be characterized.

Place, publisher, year, edition, pages
2015. Vol. 13, no 11, 722-736 p.
National Category
Genetics Microbiology Biochemistry and Molecular Biology
Research subject
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-133869DOI: 10.1038/nrmicro3569PubMedID: 26411297OAI: oai:DiVA.org:umu-133869DiVA: diva2:1089486
Available from: 2017-04-19 Created: 2017-04-19 Last updated: 2017-04-19

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Charpentier, Emmanuelle
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Molecular Infection Medicine Sweden (MIMS)Department of Molecular Biology (Faculty of Medicine)Umeå Centre for Microbial Research (UCMR)
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CiteExportLink to record
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