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Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
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2017 (English)In: Bulletin of experimental biology and medicine, ISSN 0007-4888, E-ISSN 1573-8221, Vol. 162, no 4, 430-432 p.Article in journal (Refereed) Published
Abstract [en]

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 162, no 4, 430-432 p.
Keyword [en]
amnesia, S100A9 fibrils, antibodies to glutamate, spatial memory, locomotor activity
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-133432DOI: 10.1007/s10517-017-3632-2ISI: 000396319700005PubMedID: 28239790OAI: oai:DiVA.org:umu-133432DiVA: diva2:1090012
Available from: 2017-04-21 Created: 2017-04-21 Last updated: 2017-04-21Bibliographically approved

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Morozova-Roche, Ludmilla A.
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Department of Medical Biochemistry and Biophysics
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