umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session
Umeå University, Faculty of Social Sciences, Department of Psychology. Department of Occupational and Public Health Sciences, University of Gävle, Sweden.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Show others and affiliations
2017 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, no 2, e013879Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants. The first hypothesis was that unexposed and symptom=-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n=-butanol exposure.

Design: Participants were exposed to 3.7 ppm n-butanol while seated in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role in the pathogenesis of MCS and other functional somatic syndromes were selected. Expression levels were compared between MCS and controls before, within 15 min after being exposed to and 4 hours after the exposure.

Settings: Participants suffering from MCS and healthy controls were recruited through advertisement at public places and in a local newspaper.

Participants: 36 participants who considered themselves sensitive were prescreened for eligibility. 18 sensitive persons fulfilling the criteria for MCS were enrolled together with 18 healthy controls.

Outcome measures: 17 genes showed sufficient transcriptional level for analysis. Group comparisons were conducted for each gene at the 3 times points and for the computed area under the curve (AUC) expression levels.

Results: MCS participants and controls displayed similar gene expression levels both at baseline and after the exposure and the computed AUC values were likewise comparable between the 2 groups. The intragroup variation in expression levels among MCS participants was noticeably greater than the controls.

Conclusions: MCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.

Place, publisher, year, edition, pages
2017. Vol. 7, no 2, e013879
National Category
Public Health, Global Health, Social Medicine and Epidemiology Psychology
Identifiers
URN: urn:nbn:se:umu:diva-133669DOI: 10.1136/bmjopen-2016-013879ISI: 000397872400106PubMedID: 28232466OAI: oai:DiVA.org:umu-133669DiVA: diva2:1090769
Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2017-05-15Bibliographically approved

Open Access in DiVA

fulltext(1247 kB)20 downloads
File information
File name FULLTEXT01.pdfFile size 1247 kBChecksum SHA-512
82cba1f13567d5303dabd02ec6690c29c618b01a7f3957e50c2ea3e07bc1c3dd00959a45a77d22b73a7b786c37ba99221bf57c4568d8113766e96c831ffcf6ad
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andersson, LinusClaeson, Anna-SaraLind, NinaNordin, Steven
By organisation
Department of Psychology
In the same journal
BMJ Open
Public Health, Global Health, Social Medicine and EpidemiologyPsychology

Search outside of DiVA

GoogleGoogle Scholar
Total: 20 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 146 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf