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Fetal-maternal outcomes and complications in pregnant women with polycystic ovary syndrome
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Obstetrik och gynekologi.
2017 (Engelska)Ingår i: Minerva Ginecologica, ISSN 0026-4784, E-ISSN 1827-1650, Vol. 69, nr 2, s. 141-149Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Earlier studies have shown that polycystic ovary syndrome (PCOS) is associated with cardiovascular disease as well as pregnancy complications. We examined whether women with PCOS have an increased risk of complications in pregnancy compared with healthy women, and if there are any correlations between complications and clinical/demographic variables before and/or in early pregnancy.

METHODS: This retrospective cohort study comprised 37 women with PCOS and 126 healthy women whose birth was recorded at Sundsvall County Hospital, Sweden, from 2009 to 2014. Medical records were searched to identify pregnancy complications, maternal outcomes, and neonatal outcomes.

RESULTS: Compared with healthy women, the women with PCOS were more likely to have a history of miscarriage (42.9% vs. 19.8% P=0.005) and undergo caesarean section (41.2% vs. 21.4%, P=0.019). They were also at increased risk of developing a complication (odds ratio 2.38, 95% CI: 1.05-5.38) or having multiple concurrent complications (odds ratio 8.27, 95% CI: 1.45-47.3). The rates of premature birth, birth weight and Apgar score at 5 min were similar between the two groups. The preconception serum testosterone concentration was positively correlated with the complication rate and negatively correlated with gestational age.

CONCLUSIONS: We found that women with PCOS are at greater risk of complications during pregnancy than healthy women, consistent with the results of earlier studies. High testosterone concentrations could be an aggravating factor in the risk of complications. Therefore, women with PCOS may require more careful monitoring during pregnancy than healthy women.

Ort, förlag, år, upplaga, sidor
Turin: Edizioni Minerva Medica , 2017. Vol. 69, nr 2, s. 141-149
Nyckelord [en]
Body Mass Index, Polycystic ovary syndrome, Pregnancy outcome, Pregnancy complications, Retrospective studies, Testosterone
Nationell ämneskategori
Reproduktionsmedicin och gynekologi
Identifikatorer
URN: urn:nbn:se:umu:diva-134184DOI: 10.23736/S0026-4784.16.03946-0PubMedID: 27310674OAI: oai:DiVA.org:umu-134184DiVA, id: diva2:1091803
Tillgänglig från: 2017-04-28 Skapad: 2017-04-28 Senast uppdaterad: 2018-06-09Bibliografiskt granskad

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