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Synthesis of Various N-Substituted 4-Aryloxy/Thiophenoxy/Thioisopropyloxy-Phthalimides
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry. Guru Nanak Dev Univ, Punjab, India.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2017 (English)In: ChemistrySelect, ISSN 2365-6549, Vol. 2, no 11, 3293-3296 p.Article in journal (Refereed) Published
Abstract [en]

N-substituted phthalimides have been used to target many biological systems with examples that are clinically used as drugs. Furthermore, N-substituted phthalimides can also be used in other settings such as in the preparation of polymers, as catalysts, and as protective groups. Because of all these important fields of application, the synthesis of phthalimides is well reported. However, synthetic methods to phthalimides with different heteroatom substituents in position 4 are lacking. The present work describes the development of robust synthetic methods to N-substituted 4-aryloxy/thiophenoxy/thioisopropyloxy-phthalimides. The developed methods allow for the introduction of these substituents through an atom efficient one-step synthesis, which gives good to excellent yields and tolerate a wide range of substituents.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 2, no 11, 3293-3296 p.
Keyword [en]
Green synthesis, Methodology and Reactions, Microwave synthesis, Nucleophilic substitution, Phthalimide
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-134548DOI: 10.1002/slct.201700721ISI: 000399332800013OAI: oai:DiVA.org:umu-134548DiVA: diva2:1093923
Available from: 2017-05-08 Created: 2017-05-08 Last updated: 2017-08-11Bibliographically approved

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