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Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Swedish Defence Research Agency, 906 21 Umeå, Sweden.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2017 (English)In: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 21, no 3, 376-389 p.Article in journal (Refereed) Published
Abstract [en]

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

Place, publisher, year, edition, pages
CELL PRESS , 2017. Vol. 21, no 3, 376-389 p.
National Category
Microbiology in the medical area Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-132788DOI: 10.1016/j.chom.2017.02.013ISI: 000396375600023PubMedID: 28279347OAI: oai:DiVA.org:umu-132788DiVA: diva2:1094962
Available from: 2017-05-11 Created: 2017-05-11 Last updated: 2017-07-03Bibliographically approved
In thesis
1. Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori
Open this publication in new window or tab >>Multifaceted adaptation in adherence by the gastric pathogen Helicobacter pylori
2017 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2017. 41 p.
Keyword
H. pylori, BabA, oligomerization, Leb, recombination, mutation, adherence, pH-sensitive, pH-resistant
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:umu:diva-137462 (URN)978-91-7601-733-3 (ISBN)
Available from: 2017-07-05 Created: 2017-07-03 Last updated: 2017-07-05Bibliographically approved

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Björnham, OscarChernov, Yevgen A.Gideonsson, PärHenriksson, SaraMendez, MelissaShevtsova, AnnaAisenbrey, ChristopherBylund, GöranSchmidt, AlexejÅberg, AnnaBrännström, KristofferRakhimova, LenaHofer, AndersÅden, JörgenMorozova-Roche, Ludmilla A.Olofsson, AndersGröbner, GerhardEsberg, AndersStrömberg, NicklasLandström, MaréneSchedin, StaffanArnqvist, AnnaBoren, Thomas
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Cell Host and Microbe
Microbiology in the medical areaMedical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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