umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
Show others and affiliations
2017 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 116, no 5, 688-696 p.Article in journal (Refereed) Published
Abstract [en]

Background: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n = 106, IHDB n = 34, GBTC n = 96) and their matched controls (1: 1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. Results: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR = 0.36; 95% CI: 0.13-0.98, Ptrend = 0.0123), but no association for copper (OR = 1.06; 95% CI: 0.45-2.46, Ptrend = 0.8878) in multivariable models. The calculated Cu/ Zn ratio showed a positive association for HCC (OR = 4.63; 95% CI: 1.41-15.27, Ptrend = 0.0135). For IHBC and GBTC, no significant associations were observed. Conclusions: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2017. Vol. 116, no 5, 688-696 p.
Keyword [en]
copper, zinc, hepatocellular carcinoma, prospective cohort, nested case-control study, cancer risk factors
National Category
Public Health, Global Health, Social Medicine and Epidemiology Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-133525DOI: 10.1038/bjc.2017.1ISI: 000395696200017PubMedID: 28152549OAI: oai:DiVA.org:umu-133525DiVA: diva2:1095612
Available from: 2017-05-15 Created: 2017-05-15 Last updated: 2017-05-15Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2018-02-28 00:00
Available from 2018-02-28 00:00

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Weiderpass, ElisabeteWerner, Mårten
By organisation
Department of Public Health and Clinical MedicineDepartment of Odontology
In the same journal
British Journal of Cancer
Public Health, Global Health, Social Medicine and EpidemiologyCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 20 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf