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Proximal versus distal nerve transfer for biceps reinnervation: a comparative study in a rat’s brachial plexus injury model
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery. Department of Hand and Plastic Surgery, Norrland’s University Hospital, Umeå, Sweden.
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2016 (English)In: Plastic and Reconstructive Surgery Global Open, ISSN 2169-7574, Vol. 4, no 12, e1130Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The exact role of proximal and distal nerve transfers in reconstruction strategies of brachial plexus injury remains controversial. We compared proximal with distal nerve reconstruction strategies in a rat model of brachial plexus injury.

METHODS: In rats, the C6 spinal nerve with a nerve graft (proximal nerve transfer model, n = 30, group A) and 50% of ulnar nerve (distal nerve transfer model, n = 30, group B) were used as the donor nerves. The targets were the musculocutaneous nerve and the biceps muscle. Outcomes were recorded at 4, 8, 12, and 16 weeks postoperatively. Outcome parameters included grooming test, biceps muscle weight, compound muscle action potentials, tetanic contraction force, and axonal morphology of the donor and target nerves.

RESULTS: The axonal morphology of the 2 donor nerves revealed no significant difference. Time interval analysis in the proximal nerve transfer group showed peak axon counts at 12 weeks and a trend of improvement in all functional and physiologic parameters across all time points with statistically significant differences for grooming test, biceps compound action potentials, tetanic muscle contraction force, and muscle weight at 16 weeks. In contrast, in the distal nerve transfer group, the only statistically significant difference was observed between the 4 and 8 week time points, followed by a plateau from 8 to 16 weeks.

CONCLUSIONS: Outcomes of proximal nerve transfers are ultimately superior to distal nerve transfers in our experimental model. Possible explanations for the superior results include a reduced need for cortical adaptation and higher proportions of motor units in the proximal nerve transfers.

Place, publisher, year, edition, pages
Wolters Kluwer, 2016. Vol. 4, no 12, e1130
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-135059DOI: 10.1097/GOX.0000000000001130PubMedID: 28293499OAI: oai:DiVA.org:umu-135059DiVA: diva2:1096410
Note

Erratum in Plast Reconstr Surg Glob Open. 2017 Apr 24;5(3):e1314

Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2017-11-02Bibliographically approved

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