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The heritable basis of gene-environment interactions in cardiometabolic traits
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
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2017 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, no 3, 442-452 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis Little is known about the heritable basis of gene-environment interactions in humans. We therefore screened multiple cardiometabolic traits to assess the probability that they are influenced by genotype-environment interactions.

Methods Fourteen established environmental risk exposures and 11 cardiometabolic traits were analysed in the VIKING study, a cohort of 16,430 Swedish adults from 1682 extended pedigrees with available detailed genealogical, phenotypic and demographic information, using a maximum likelihood variance decomposition method in Sequential Oligogenic Linkage Analysis Routines software.

Results All cardiometabolic traits had statistically significant heritability estimates, with narrow-sense heritabilities (h (2)) ranging from 24% to 47%. Genotype-environment interactions were detected for age and sex (for the majority of traits), physical activity (for triacylglycerols, 2 h glucose and diastolic BP), smoking (for weight), alcohol intake (for weight, BMI and 2 h glucose) and diet pattern (for weight, BMI, glycaemic traits and systolic BP). Genotype-age interactions for weight and systolic BP, genotype-sex interactions for BMI and triacylglycerols and genotype-alcohol intake interactions for weight remained significant after multiple test correction.

Conclusion/hypothesis Age, sex and alcohol intake are likely to be major modifiers of genetic effects for a range of cardiometabolic traits. This information may prove valuable for studies that seek to identify specific loci that modify the effects of lifestyle in cardiometabolic disease.

Place, publisher, year, edition, pages
SPRINGER , 2017. Vol. 60, no 3, 442-452 p.
Keyword [en]
Cardiometabolic traits, Environment, Extended pedigrees, Gene, Heritability, Interaction, VIKINGstudy
National Category
Public Health, Global Health, Social Medicine and Epidemiology Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-133524DOI: 10.1007/s00125-016-4184-0ISI: 000394462100010PubMedID: 28004149OAI: oai:DiVA.org:umu-133524DiVA: diva2:1096961
Available from: 2017-05-20 Created: 2017-05-20 Last updated: 2017-05-22Bibliographically approved

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Brändström, AndersEngberg, ElisabethHallmans, GöranJohansson, IngegerdRenström, FridaFranks, Paul W.
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Centre for Demographic and Ageing Research (CEDAR)Department of Biobank ResearchMedicine
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Diabetologia
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CiteExportLink to record
Permanent link

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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
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  • en-US
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  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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  • text
  • asciidoc
  • rtf