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ICL-based TDLAS sensor for real-time breath gas analysis of carbon monoxide isotopes
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. (Applied Laser Spectroscopy)
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. (Applied Laser Spectroscopy, TEC-Lab)ORCID iD: 0000-0002-5065-7786
2017 (English)In: Optics Express, ISSN 1094-4087, Vol. 25, no 11, 12743-12752 p.Article in journal (Refereed) Published
Abstract [en]

We present a compact sensor for carbon monoxide (CO) in air and exhaled breath based on a room temperature interband cascade laser (ICL) operating at 4.69 µm, a low-volume circular multipass cell and wavelength modulation absorption spectroscopy. A fringe-limited (1σ) sensitivity of 6.5 × 10−8 cm−1Hz-1/2 and a detection limit of 9 ± 5 ppbv at 0.07 s acquisition time are achieved, which constitutes a 25-fold improvement compared to direct absorption spectroscopy. Integration over 10 s increases the precision to 0.6 ppbv. The setup also allows measuring the stable isotope 13CO in breath. We demonstrate quantification of indoor air CO and real-time detection of CO expirograms from healthy non-smokers and a healthy smoker before and after smoking. Isotope ratio analysis indicates depletion of 13CO in breath compared to natural abundance.

Place, publisher, year, edition, pages
OSA , 2017. Vol. 25, no 11, 12743-12752 p.
Keyword [en]
Laser sensors; Spectroscopy, infrared; Spectroscopy, laser; Biological sensing and sensors ; Semiconductor lasers, quantum cascade
National Category
Medical Laboratory and Measurements Technologies Atom and Molecular Physics and Optics Physical Chemistry Physiology
Identifiers
URN: urn:nbn:se:umu:diva-135377DOI: 10.1364/OE.25.012743OAI: oai:DiVA.org:umu-135377DiVA: diva2:1098658
Available from: 2017-05-24 Created: 2017-05-24 Last updated: 2017-05-24

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Publisher's full texthttp://www.opticsexpress.org/abstract.cfm?URI=oe-25-11-12743

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Ghorbani, RaminSchmidt, Florian M.
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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf