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Real-time breath gas analysis of CO and CO2 using an EC-QCL
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. (Applied Laser Spectroscopy)
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. (Applied Laser Spectroscopy, TEC-Lab)ORCID iD: 0000-0002-5065-7786
2017 (English)In: Applied physics. B, Lasers and optics (Print), ISSN 0946-2171, E-ISSN 1432-0649, Vol. 123, no 5, 144Article in journal (Refereed) Published
Abstract [en]

Real-time breath gas analysis is a promising, non-invasive tool in medical diagnostics, and well-suited to investigate the physiology of carbon monoxide (CO), a potential biomarker for oxidative stress and respiratory diseases. A sensor for precise, breath-cycle resolved, simultaneous detection of exhaled CO (eCO) and carbon dioxide (eCO2) was developed based on a continuous wave, external-cavity quantum cascade laser (EC-QCL), a low-volume multi-pass cell and wavelength modulation spectroscopy. The system achieves a noise-equivalent (1σ) sensitivity of 8.5 × 10−8 cm−1 Hz−1/2 and (2σ) detection limits of 9 ± 2 ppbv and 650 ± 7 ppmv at 0.14 s spectrum acquisition time for CO and CO2, respectively. Integration over 15 s yields a precision of 0.6 ppbv for CO. The fact that the eCO2 expirograms measured by capnography and laser spectroscopy have essentially identical shape confirms true real-time detection. It is found that the individual eCO exhalation profiles from healthy non-smokers have a slightly different shape than the eCO2 profiles and exhibit a clear dependence on exhalation flow rate and breath-holding time. Detection of indoor air CO and broadband breath profiling across the 93 cm−1 mode-hop-free tuning range of the EC-QCL are also demonstrated.

Place, publisher, year, edition, pages
Springer, 2017. Vol. 123, no 5, 144
National Category
Atom and Molecular Physics and Optics Medical Laboratory and Measurements Technologies Physiology
Identifiers
URN: urn:nbn:se:umu:diva-135366DOI: 10.1007/s00340-017-6715-xISI: 000402982600006OAI: oai:DiVA.org:umu-135366DiVA: diva2:1098659
Available from: 2017-05-24 Created: 2017-05-24 Last updated: 2017-07-04Bibliographically approved

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Ghorbani, RaminSchmidt, Florian M.
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Applied physics. B, Lasers and optics (Print)
Atom and Molecular Physics and OpticsMedical Laboratory and Measurements TechnologiesPhysiology

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CiteExportLink to record
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Citation style
  • apa
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