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The pancreas
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). (Ulf Ahlgren)
Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM). (Ulf Ahlgren)
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2015 (English)In: Kaufman's atlas of mouse development supplement: with coronal sections / [ed] Richard Baldock, Jonathan Bard, Duncan R. Davidson and Gillian Morriss-Kay, Elsevier, 2015, 1, p. 85-94Chapter in book (Refereed)
Abstract [en]

This chapter aims to provide a three-dimensional description of the key morphological events, through which a discrete region of the early gut epithelium, as well as its associated mesenchyme, gives rise to the adult pancreas. Facilitated by recent advances in optical imaging techniques, including light sheet fluorescence microscopy and optical projection tomography, we present image series illustrating the growth of the organ and the formation of key morphological and anatomical features. Given the close developmental relationship between the pancreas-associated mesenchyme and the spleen anlage, and thus the potential for the developing spleen to influence pancreas morphogenesis, we include a brief section which covers the early development of this organ. Finally, we describe the spatial and quantitative distribution of the pancreatic endocrine (β-cell) component in adult mice and highlight lobular heterogeneities that may affect phenotypical evaluations of the gland.

Place, publisher, year, edition, pages
Elsevier, 2015, 1. p. 85-94
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-134657ISBN: 978-0-12-800043-4 (print)ISBN: 978-0-12-800913-0 (electronic)OAI: oai:DiVA.org:umu-134657DiVA, id: diva2:1104364
Available from: 2017-06-01 Created: 2017-06-01 Last updated: 2018-02-05Bibliographically approved

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Hörnblad, AndreasNord, ChristofferParween, SabaAhlgren, Ulf
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