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Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2017 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 6, e15651Article in journal (Refereed) Published
Abstract [en]

Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Nasstrom et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients. After comparing the direction of change and degree of multivariate significance, we identified 24 metabolites that were consistently up- or down regulated in a further Bangladeshi/Senegalese validation cohort, and the Nepali cohort from our previous work. We have identified and validated a metabolite panel that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2017. Vol. 6, e15651
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-135532DOI: 10.7554/eLife.15651ISI: 000400828100001OAI: oai:DiVA.org:umu-135532DiVA: diva2:1108858
Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2017-07-06Bibliographically approved

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Näsström, ElinRzhepishevska, OlenaJohansson, AndersAntti, Henrik
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Department of ChemistryDepartment of Clinical Microbiology
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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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  • asciidoc
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