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Lower cognitive performance among long-term type 1 diabetes survivors: A case-control study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine. Department of Public Health and Clinical Medicine, Sunderby Research Unit, Umeå University, Sweden..
Research and Innovation Unit, Norrbotten County Council, Luleå, Sweden..
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Social Sciences, Department of Psychology. Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR). (Centre of Demographic and Ageing Research (CEDAR), Umeå University, Sweden.)
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2017 (English)In: Journal of diabetes and its complications, ISSN 1056-8727, E-ISSN 1873-460X, Vol. 31, no 8, 1328-1331 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Patients with type 1 diabetes (T1D) have an increased risk of cognitive dysfunction. The cognitive decrement is believed to depend on macro- and microvascular complications and long disease duration. Some patients do not develop these complications, but still report cognitive symptoms. We examined if long-standing T1D without complications is associated with lower cognitive performance.

METHODS: A group of patients (n=43) with long-standing T1D (>30years) without micro- or macro vascular complications was compared with a non-diabetic control group (n=86) on six cognitive tests which probed episodic memory, semantic memory, episodic short-term memory, visual attention and psychomotor speed. Each patient was matched with two controls regarding age, gender and education. A linear mixed effect model was used to analyze the data.

RESULTS: The mean age was 57years and mean duration was 41years. Patients with diabetes had lower diastolic blood pressure but BMI, waist circumference, systolic blood pressure and smoking did not differ between groups. Patients had lower results than non-diabetic controls in episodic short-term memory (p<0.001) and also lower values on a test that mirrors visual attention and psychomotor speed (p=0.019).

CONCLUSIONS: Long-standing T1D was associated with lower cognitive performance, regardless of other diabetes-related complications.

Place, publisher, year, edition, pages
Elsevier , 2017. Vol. 31, no 8, 1328-1331 p.
Keyword [en]
Cognition, Complications, Memory, Psychomotor speed, Type 1-diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-136399DOI: 10.1016/j.jdiacomp.2017.04.023ISI: 000406081200016PubMedID: 28579311OAI: oai:DiVA.org:umu-136399DiVA: diva2:1110800
Available from: 2017-06-16 Created: 2017-06-16 Last updated: 2017-08-10Bibliographically approved

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Rolandsson, OlovSundström, AnnaEliasson, Mats
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