Energy use on heating, ventilation and air conditioning (HVAC) accounts for about 50% of total energy use in buildings. Energy efficient HVAC systems that do not compromise the indoor environmental quality and at the same time meet the energy reduction directives/policies are necessary and needed. The study herein, evaluates the energy saving potential of a newly proposed ventilation system in spaces with high occupancy density, called Intermittent Air Jet Strategy (IAJS). The aim of the study was to evaluate through simulations the potential energy savings due to IAJS as compared to a mixing ventilation (MV) system in a classroom located in a ‘hot and humid’ climate (Singapore), and in a ‘hot and dry’ climate (Kuwait). The analysis is based on IDA Indoor Climate Energy simulation software. The results herein demonstrate significant reduction of cooling energy use of up 54.5% for Singapore and up to 32.2% for Kuwait with IAJS as compared to MV. Additionally, supply fan energy savings can also be realized if well implemented.