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Brain volume alterations in children born preterm: Associations with gestational age and auditory laterality
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Social Sciences, Department of Psychology.
2017 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Children born preterm (PT) are at high risk for long-term consequences such as cortical alterations, adverse neurodevelopmental outcomes, and atypical lateralization. This study investigated brain volume alterations, auditory laterality, and associations with gestational age (GA) in children born PT compared to full-term (FT) born controls. In addition, possible associations between right-ear-advantage (REA) and hemispheric volumes at regions of interest linked with auditory processing (ROI-14) were explored. The sample consisted of 60 children (Mage = 8.17 years, SD = .64); 27 born PT (GA range 25–35.4) and 33 born FT (GA 38–41.9). Based on GA, the PT group was subdivided into extremely PT (EPT, n = 6), very PT (VPT, n = 9), and moderately PT (MPT, n = 12). The brain volumes were measured by 3.0-Tesla Magnetic Resonance Imaging (MRI), using Synthetic MRI acquisition and software. Ear-advantage was measured with the dichotic listening paradigm. The results showed reduced brain volumes and more cerebrospinal fluid in children born EPT and VPT. Moreover, the reduced brain volumes were associated with lower GA in the PT group. Despite no evidence of strong REA in either of the groups, the REA was more prominent and negatively associated with white matter of both hemispheres at ROI-14 in the PT group. In conclusion, long-term effects of a PT birth, particularly with lower GA, are associated with delayed brain maturation seen by volumetric alterations. Furthermore, white matter volumes appear more critical to auditory laterality at early school-age in children born PT than in their FT born peers. 

Abstract [sv]

Barn födda prematurt (PT) löper hög risk för långsiktiga konsekvenser, till exempel kortikala variationer, negativ neuroutveckling och atypisk lateralisering. Denna studie undersökte variationer i hjärnvolymer, auditiv lateralitet och samband med gestationsålder (GA) hos barn födda PT jämfört med fullgångna (FT) kontroller. Dessutom utforskades möjliga samband mellan höger-öra-fördel (REA) och hemisfärsvolymer i ett område av intresse relaterat till auditivt processande (ROI-14). Urvalet bestod av 60 barn (Målder = 8.17 år, SD = .64); 27 födda PT (GA-spann 25–35.4) och 33 födda FT (GA 38–41.9). PT-gruppen delades upp ytterligare utifrån GA i extremt PT (EPT, n = 6), mycket PT (VPT, n = 9) och måttligt PT (MPT, n = 12). Hjärnvolymerna mättes med 3.0-Tesla magnetresonansavbildning (MRI) genom att använda Syntetisk MR-sekvens och programvara. Öra-fördel mättes med dikotisk lyssningsparadigmet. Resultaten visade på minskade hjärnvolymer och mer cerebrospinalvätska hos barn födda EPT och VPT. Dessutom hade de minskade hjärnvolymerna ett samband med lägre GA i PT-gruppen. Trots att ingen av grupperna uppvisade en stark REA, var REA mer framträdande och hade ett negativt samband med vit substans i båda hemisfärerna på ROI-14 i PT-gruppen. Sammanfattningsvis har långsiktiga konsekvenser av att födas PT, särskilt med lägre GA, samband med försenad hjärnutveckling som tar sig uttryck genom variationer i volym. Dessutom verkar vit substans ha större betydelse för auditiv lateralitet i tidig skolålder hos barn födda PT, än hos deras FT-födda jämnåriga. 

Place, publisher, year, edition, pages
2017. , 18 p.
Keyword [en]
Preterm, children, brain volumes, auditory laterality, right-ear-advantage, Synthetic MR
Keyword [sv]
Prematur, barn, hjärnvolymer, auditiv lateralitet, höger-öra-fördel, Syntetisk MR
National Category
Psychology
Identifiers
URN: urn:nbn:se:umu:diva-136593OAI: oai:DiVA.org:umu-136593DiVA: diva2:1112349
Educational program
Study Programme for University Diploma in Psychology
Supervisors
Examiners
Available from: 2017-06-21 Created: 2017-06-20 Last updated: 2017-06-21Bibliographically approved

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Citation style
  • apa
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More styles
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