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Levels of oxylipins, endocannabinoids and related lipids in plasma before and after low-level exposure to acrolein in healthy individuals and individuals with chemical intolerance
Umeå University, Faculty of Social Sciences, Department of Psychology.ORCID iD: 0000-0001-5026-4934
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
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2017 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 121, 60-67 p.Article in journal (Refereed) Published
Abstract [en]

Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin. Participants were exposed twice (60 min) to heptane and a mixture of heptane and acrolein. Blood samples were collected before exposure, after and 24 h post-exposure. There were no overt effects of acrolein exposure on the oxylipin lipidome or endocannibinoids detectable in the bloodstream at the time points investigated. No relationship between basal levels or levels after exposure to acrolein and CI could be identified. This implicates a minor role of inflammatory mediators on the systemic level in CI.

Place, publisher, year, edition, pages
2017. Vol. 121, 60-67 p.
Keyword [en]
Oxylipins, Endocannabinoids, Plasma, Human exposure, Acrolein, Chemical intolerance
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-136786DOI: 10.1016/j.plefa.2017.06.004ISI: 000405763500009OAI: oai:DiVA.org:umu-136786DiVA: diva2:1113757
Funder
Swedish Research Council Formas, 2010-1401
Available from: 2017-06-22 Created: 2017-06-22 Last updated: 2017-08-18Bibliographically approved

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Claeson, Anna-SaraGouveia-Figueira, SandraHäggström, JennyFowler, Christopher J.Nording, Malin L.
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Department of PsychologyDepartment of ChemistryStatisticsDepartment of Pharmacology and Clinical Neuroscience
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Prostaglandins, Leukotrienes and Essential Fatty Acids
Environmental Health and Occupational Health

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