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Deep Brain Stimulation Improves Brain Efficiency in Essential Tremor Patients
Umeå University, Faculty of Social Sciences, Department of Psychology. (UFBI)
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The movement disorder essential tremor can be treated with deep brain stimulation (DBS), where electric current is delivered to deep brain structures through permanently implanted electrodes. In this study, brain activity during working memory performance was measured with functional magnetic resonance imaging in thirteen essential tremor patients with DBS in caudal Zona incerta, a diencephalic nucleus. With active stimulation less exertion of certain working memory areas was required to achieve the same level of performance in a manipulation and a maintenance-type working memory task. At the same time, a relatively higher activation was reached for the more demanding manipulation task. These results indicate that DBS can make the brains of tremor patients more efficient in working memory tasks, in accordance with the “efficiency hypothesis” proposed by Nyberg et al. (2014).

Abstract [sv]

Rörelsestörningen essentiell tremor kan behandlas med djup hjärnstimulering (DBS), vid vilken elektrisk ström tillförs djupa hjärnstrukturer genom permanent inopererade elektroder. I den här studien mättes hjärnaktivering under arbetsminnesbelastning med funktionell magnetresonans-tomografi hos tretton essentiell tremor-patienter med DBS i kaudala Zona incerta, en kärna i mellanhjärnan. Med stimuleringen påslagen krävdes en lägre hjärnaktivering i arbetsminnes-relaterade områden för att nå samma resultat i två arbetsminnesuppgifter där den enda krävde manipulation och den andra enbart kvarhållande av information. Samtidigt kunde en relativt sett högre aktiveringsnivå uppnås för den mer krävande manipulationsuppgiften. De här resultaten tyder på att DBS kan göra tremorpatienters hjärna mer effektiv i arbetsminnesuppgifter, i enlighet med den “effektivitetshypotes” som lagts fram av Nyberg m fl (2014).

Place, publisher, year, edition, pages
2017. , 27 p.
Keyword [en]
Deep brain stimulation, Essential tremor, Working memory, fMRI, DBS, ET, WM
National Category
Psychology
Identifiers
URN: urn:nbn:se:umu:diva-136866OAI: oai:DiVA.org:umu-136866DiVA: diva2:1114322
Subject / course
Masteruppsats i kognitionsvetenskap
Educational program
Master's Programme in Cognitive Science
Supervisors
Available from: 2017-06-28 Created: 2017-06-22 Last updated: 2017-06-28Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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