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Short-term olfactory sensitization involves brain networks relevant for pain, and indicates chemical intolerance
Umeå University, Faculty of Social Sciences, Department of Psychology. Department of Occupational and Public Health Sciences, University of Gävle, Sweden.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Social Sciences, Department of Psychology.
2017 (English)In: International journal of hygiene and environmental health (Print), ISSN 1438-4639, E-ISSN 1618-131X, Vol. 220, no 2, 503-509 p.Article in journal (Refereed) Published
Abstract [en]

Chemical intolerance is a medically unexplained affliction that implies deleterious reactions to non-toxic everyday chemical exposure. Sensitization (i.e. increased reactivity to repeated, invariant stimulation) to odorous stimulation is an important component in theoretical explanations of chemical intolerance, but empirical evidence is scarce. We hypothesized that (1) individuals who sensitize to repeated olfactory stimulation, compared with those who habituate, would express a lower blood oxygenated level dependent (BOLD) response in key inhibitory areas such as the rACC, and higher signal in pain/saliency detection regions, as well as primary and/or secondary olfactory projection areas; and (2) olfactory sensitization, compared with habituation, would be associated with greater self-reported chemical intolerance. More-over, we assessed whether olfactory sensitization was paralleled by comparable trigeminal processing - in terms of perceptual ratings and BOLD responses. We grouped women from a previous functional magnetic imaging study based on intensity ratings of repeated amyl acetate exposure over time. Fourteen women sensitized to the exposure, 15 habituated, and 20 were considered "intermediate" (i.e. neither sensitizers nor habituaters). Olfactory sensitizers, compared with habituaters, displayed a BOLD-pattern in line with the hypothesis, and reported greater problems with odours in everyday life. They also expressed greater reactions to CO2 in terms of both perceived intensity and BOLD signal. The similarities with pain are discussed.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 220, no 2, 503-509 p.
Keyword [en]
Chemical intolerance, Olfactory, Trigeminal, Sensitization, Smell, fMRI
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-135983DOI: 10.1016/j.ijheh.2017.02.002ISI: 000401215300022PubMedID: 28254164OAI: oai:DiVA.org:umu-135983DiVA: diva2:1114874
Note

Part B.

Available from: 2017-06-26 Created: 2017-06-26 Last updated: 2017-06-26Bibliographically approved

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Andersson, LinusClaeson, Anna-SaraNyberg, LarsNordin, Steven
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Department of PsychologyDepartment of Integrative Medical Biology (IMB)Department of Radiation Sciences
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