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Inosine triphosphate pyrophosphatase enhances the effect of ribavirin on hepatitis C virus cell culture infection
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2017 (English)In: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 66, no 1, S321-S321 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Genetic variants of the inosine triphosphate pyrophosphatase gene (ITPA), resulting in decreased enzymatic activity of the corresponding enzyme, ITPase, are known to correlate with a decreased risk of ribavirin-induced anemia, but are also associated with an increased SVR in patients treated with peginterferon-alpha and ribavirin. As both ITPase and ribavirin are involved in the nucleotide salvage pathway and reduced risk of relapse after treatment of hepatitis C, we have investigated the effect of ITPase activity and ribavirin treatment of HCVcc infection of hepatocytes

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 66, no 1, S321-S321 p.
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:umu:diva-137018ISI: 000401056600702OAI: oai:DiVA.org:umu-137018DiVA: diva2:1117604
Conference
International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, APR 19-23, 2017, Amsterdam, NETHERLANDS
Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2017-06-29Bibliographically approved

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Wanrooij, PaulinaChabes, Andrei
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Department of Medical Biochemistry and Biophysics
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