umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Enlarged left atrium and increased basal heart rate predict exercise capacity in heart failure patients
Show others and affiliations
2017 (English)In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, no S1, p. 582-583, article id P2260Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background and aim: Heart failure (HF) is a major and growing health problem characterized by high mortality, frequent hospitalization, reduced quality of life and a complex therapeutic regimen. Six minute walking test (6-MWT) may serve as a reproducible test for assessing exercise capacity in HF patients and can be clinically predicted. The aim of this study was to assess clinical, biochemical and echocardiographical predictors of limited exercise capacity in HF patients.

Methods: The study subjects were 135 consecutive clinically stable HF patients (64±11 years, 66 [47%] female, classified as NYHA I-III). Echocardiography, including tissue Doppler measurements, was performed in all patients. A six minute walk test (6-MWT) distance was performed in all patients, who were divided into two groups based on the 6-MWT distance (Group I: ≤ 300 m and Group II: >300 m).

Results: Patients with limited exercise performance (≤ 300 m) were older (p<001), more frequent female (p=0.007) and diabetics (p=0.003), had lower level of hemoglobin (p=0.02), larger left atrium (LA, p=0.003), higher basal heart rate (p=0.009), higher E/e’ ratio (p=0.01) and lower septal systolic myocardial velocity (p=0.03) compared with good performance patients. Enlarged LA [2.856 (1.439-5.666), p=0.003], older age [1.110 (1.036-1.188), p=0.003], increased basal heart rate [1.055 (1.012-1.099), p=0.012] and the presence of diabetes [3.321 (1.022-10.796), p=0.046] independently predicted poor 6-MWT performance.

Conclusions: In patients with HF, the limited exercise capacity assessed by 6-MWT, is related mostly to the enlarged left atrium as e reflection of longstanding increased left ventricular filling pressure, increased basal heart rate, in addition to the older age and the presence of diabetes. These findings highlights the need of the optimal medical treatment of HF patients towards the decreasing LV filling pressure and heart rate.

Place, publisher, year, edition, pages
European Society of Cardiology , 2017. Vol. 19, no S1, p. 582-583, article id P2260
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-136989DOI: 10.1002/ejhf.833ISI: 000401005301841OAI: oai:DiVA.org:umu-136989DiVA, id: diva2:1117849
Note

Abstracts of the Heart Failure 2017 and the 4th World Congress on Acute Heart Failure, Paris, France, 29 April – 2 May 2017

Available from: 2017-06-29 Created: 2017-06-29 Last updated: 2020-03-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Henein, Mark

Search in DiVA

By author/editor
Henein, Mark
By organisation
Medicine
In the same journal
European Journal of Heart Failure
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 20 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf