umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Risk Factors for Pulmonary Arterial Hypertension in Children and Young Adults
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. Unit of Research Education and Development, Östersund Hospital, Östersund, Sweden.
2017 (English)In: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 52, no 5, 636-641 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: Pulmonary hypertension (PH) has been linked to preterm birth explained by congenital heart defects and pulmonary diseases. Working hypothesis: Other factors may influence the risk of PH among adolescences and children born premature. Study design: This national registry-based study assess risk of PH following premature birth adjusted for known risk factors. Patient-subject selection and methodology: All cases born 1993-2010, identified by diagnostic codes applicable to PH and retrieved from the Swedish Registry of Congenital Heart Disease (N = 67). Six controls were randomly selected and matched to each case by year of birth and hospital by the Swedish Medical Birth Register (N = 402). Maternal and infant data related to preterm birth, pulmonary diseases, and congenital defects were retrieved. The association between preterm birth and pulmonary hypertension was calculated by conditional logistic regression taking into account potential confounding factors. Results: One third of the cases and seven percent of the controls were born preterm in our study. Preterm birth was associated with PH, OR = 8.46 (95% CI 2.97-24.10) (P < 0.0001) even after adjusting for confounding factors. Other factors, such as acute pulmonary diseases, congenital heart defects, congenital diaphragm herniation, and chromosomal disorders were also associated with PH in the multivariate analysis. Conclusions: Children and young adults born preterm are known to have an increased risk of PH, previously explained by congenital heart defects and pulmonary diseases. By adjusting for such factors, our study indicates that new factors may play a role in the risk of developing PH among children born preterm. 

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 52, no 5, 636-641 p.
Keyword [en]
bronchopulmonary dysplasia, chronic lung disease of the newborn, congenital diaphragm herniation, eterm birth, pulmonary hypertension
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-136205DOI: 10.1002/ppul.23633ISI: 000400375600011PubMedID: 27801982OAI: oai:DiVA.org:umu-136205DiVA: diva2:1119084
Available from: 2017-07-03 Created: 2017-07-03 Last updated: 2017-07-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Naumburg, Estelle
By organisation
Paediatrics
In the same journal
Pediatric Pulmonology
Pediatrics

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 3 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf