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The neuroscience and context of adolescent depression.
Karolinska Institutet, University of California San Francsisco. (Barn- och Ungdomspsykiatri)ORCID iD: 0000-0001-5790-0518
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2016 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 105, no 4, 358-65 p.Article in journal (Refereed) Published
Abstract [en]

UNLABELLED: Adolescent depression is a growing public health concern with an increased risk of negative health outcomes, including suicide. The use of antidepressants and psychotherapy has not halted its increasing prevalence, and there is a critical need for effective prevention and treatment. We reviewed the neuroscience of adolescent depression, with a focus on the neurocircuitry of sustained threat and summarised contextual factors that have an impact on brain development and the pathophysiology of depression. We also reviewed novel treatment models.

CONCLUSION: Attention to the relevant neurocircuitry and contextual factors implicated in adolescent depression is necessary to advance prevention and treatment development.

Place, publisher, year, edition, pages
2016. Vol. 105, no 4, 358-65 p.
Keyword [en]
Adolescent depression, Contextual factors, Neuroscience, Review, Sustained threat
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:umu:diva-135778DOI: 10.1111/apa.13299PubMedID: 26663379OAI: oai:DiVA.org:umu-135778DiVA: diva2:1120547
Available from: 2017-07-06 Created: 2017-07-06 Last updated: 2017-07-06

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Henje Blom, Eva
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