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Diversity-Oriented Synthesis of Libraries Based on Benzofuran and 2,3-Dihydrobenzofuran Scaffolds
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2017 (English)In: ACS Combinatorial Science, ISSN 2156-8952, Vol. 19, no 6, 370-376 p.Article in journal (Refereed) Published
Abstract [en]

Benzofuran and 2,3-dihydrobenzofuran scaffolds are core components in a large number of biologically active natural and synthetic compounds including approved drugs. Herein, we report efficient synthetic protocols for preparation of libraries based on 3-carboxy 2-aryl benzofuran and 3-carboxy 2-aryl trans-2,3-dihydrobenzofuran scaffolds using commercially available salicylaldehydes, aryl boronic acids or halides and primary or secondary amines. The building blocks were selected to achieve variation in physicochemical properties and statistical molecular design and subsequent synthesis resulted in 54 lead-like compounds with molecular weights of 299-421 and calculated octanol/water partition coefficients of 1.9-4.7.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 19, no 6, 370-376 p.
Keyword [en]
diversity oriented synthesis, benzofuran, 2, 3-dihydrobenzofuran
National Category
Chemical Sciences Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-137641DOI: 10.1021/acscombsci.7b00014ISI: 000403387200004PubMedID: 28306238OAI: oai:DiVA.org:umu-137641DiVA: diva2:1124457
Available from: 2017-07-13 Created: 2017-07-13 Last updated: 2017-07-13Bibliographically approved

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Qin, LienaVo, Duc-DuyNakhai, AzadehAndersson, C. DavidElofsson, Mikael
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