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The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynecology.
2017 (English)In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 6, no 4, 253-259 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role. Allopregnanolone, a progesterone metabolite, increases during pregnancy and is a potent GABA-A receptor modulating steroid. Allopregnanolone has been shown to induce overeating in rodents. The aim was to investigate whether there is a relationship between weight gain and allopregnanolone concentrations during pregnancy in humans. Design: A longitudinal, cohort study. Methods: Pregnant women (n = 56) were recruited in primary care in northern Sweden. Allopregnanolone concentrations in plasma were measured using radioimmunoassay and weight was measured in gestational weeks 12 and 35. Results: Weight increase correlated significantly to allopregnanolone in late pregnancy increase (r(s) = 0.320; P = 0.016), indicating a positive relationship between weight increase and allopregnanolone increase. A positive relationship was also noted between allopregnanolone in the 35th gestational week and weight increase. Women who gained = 11 kg during pregnancy showed higher allopregnanolone concentrations in week 35 and higher increase compared to women who increased < 11 kg (P = 0.006 and P = 0.009 resp.). There was no difference in weight or allopregnanolone concentrations at the onset of pregnancy. Conclusions: The results show a relationship between weight gain during pregnancy and increase in allopregnanolone concentrations.

Place, publisher, year, edition, pages
Bioscientifica, 2017. Vol. 6, no 4, 253-259 p.
Keyword [en]
allopregnanolone, pregnancy, weight increase, longitudinal
National Category
Obstetrics, Gynecology and Reproductive Medicine Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-137986DOI: 10.1530/EC-17-0046ISI: 000404927100012PubMedID: 28381564OAI: oai:DiVA.org:umu-137986DiVA: diva2:1129083
Available from: 2017-08-01 Created: 2017-08-01 Last updated: 2017-08-01Bibliographically approved

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Lundqvist, AnetteSandström, HerbertBäckström, Torbjörn
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CiteExportLink to record
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Citation style
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