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Determinants of Bacterial Morphology: From Fundamentals to Possibilities for Antimicrobial Targeting
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2017 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 8, 1264Article in journal (Refereed) Published
Abstract [en]

Bacterial morphology is extremely diverse. Specific shapes are the consequence of adaptive pressures optimizing bacterial fitness. Shape affects critical biological functions, including nutrient acquisition, motility, dispersion, stress resistance and interactions with other organisms. Although the characteristic shape of a bacterial species remains unchanged for vast numbers of generations, periodical variations occur throughout the cell (division) and life cycles, and these variations can be influenced by environmental conditions. Bacterial morphology is ultimately dictated by the net-like peptidoglycan (PG) sacculus. The species-specific shape of the PG sacculus at any time in the cell cycle is the product of multiple determinants. Some morphological determinants act as a cytoskeleton to guide biosynthetic complexes spatiotemporally, whereas others modify the PG sacculus after biosynthesis. Accumulating evidence supports critical roles of morphogenetic processes in bacteria-host interactions, including pathogenesis. Here, we review the molecular determinants underlying morphology, discuss the evidence linking bacterial morphology to niche adaptation and pathogenesis, and examine the potential of morphological determinants as antimicrobial targets.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2017. Vol. 8, 1264
Keyword [en]
bacterial morphology, peptidoglycan, cytoskeleton, antimicrobials, cell shape inhibitors
National Category
Microbiology
Identifiers
URN: urn:nbn:se:umu:diva-137944DOI: 10.3389/fmicb.2017.01264ISI: 000405231400001OAI: oai:DiVA.org:umu-137944DiVA: diva2:1129443
Available from: 2017-08-03 Created: 2017-08-03 Last updated: 2017-08-03Bibliographically approved

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van Teeseling, Muriel C. F.Cava, Felipe
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Molecular Infection Medicine Sweden (MIMS)Department of Molecular Biology (Faculty of Medicine)Umeå Centre for Microbial Research (UCMR)
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Frontiers in Microbiology
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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
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  • vancouver
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More styles
Language
  • de-DE
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  • Other locale
More languages
Output format
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