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An ex vivo model using human peritoneum to explore mesh-tissue integration.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. (Clister)
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery. (Clister)
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2017 (English)In: Biology open, ISSN 2046-6390, bio.024992Article in journal (Refereed) Epub ahead of print
Abstract [en]

Biological compatibility, in terms of implantation of foreign mesh material in hernia surgery, still needs experimental investigation. Present study develops an experimental model using human peritoneum to study the integration between tissue and different mesh material. The ex vivo model using peritoneal tissue was studied with different mesh material, and integration was monitored over time using microscopy.It could be demonstrated that the peritoneal model may be kept viable in culture for several weeks. Cell migration was seen after 7-10 days in culture and could be further monitored over several weeks. The use of a human artificial model environment enabling the investigation of tissue/mesh integration has, to our knowledge, not been described previously.This proof-of-concept model was developed, for the investigation of peritoneal biology and the integration between tissue and different mesh material. It has the potential to be useful in studies on other important biological mechanisms involving the peritoneum.

Place, publisher, year, edition, pages
2017. bio.024992
Keyword [en]
Biocompatibility, Experimental model, Mesh, Peritoneal tissue, Peritoneum, Synthetic mesh
National Category
Surgery
Identifiers
URN: urn:nbn:se:umu:diva-138063DOI: 10.1242/bio.024992PubMedID: 28760734OAI: oai:DiVA.org:umu-138063DiVA: diva2:1129566
Available from: 2017-08-04 Created: 2017-08-04 Last updated: 2017-08-04

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